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Remdesivir shows ‘clear-cut’ effect in treating coronavirus ― US

Posted By Kenneth nwakauba | In Health | Apr 30, 2020, 10:02 am

Coronavirus patients on the antiviral remdesivir recovered more than 30 per cent faster than those on a placebo, the results of a major clinical trial showed Wednesday as a top US scientist hailed the drug’s “clear-cut” benefit.

It represents the first time any medication has been shown to improve outcomes against the coronavirus illness, which has claimed more than 200,000 lives globally and brought the world economy to a grinding halt.

Anthony Fauci, who oversaw the investigation, told reporters at the White House: “The data shows that remdesivir has a clear-cut, significant, positive effect in diminishing the time to recovery.”

He added that the trial was proof “that a drug can block this virus,” and compared the finding to the arrival of the first antiretrovirals that worked against HIV in the 1980s, albeit with modest success at first.

A statement by the National Institute of Allergy and Infectious Diseases that Fauci heads said that patients on the drug had a 31 per cent faster time to recovery than those on a placebo.

“Specifically, the median time to recovery was 11 days for patients treated with remdesivir compared with 15 days for those who received placebo,” it said.

The results also suggested that people who were on the drug were less likely to die, although the difference was not huge: The mortality rate was 8.0 per cent for the group receiving remdesivir versus 11.6 per cent for the placebo group.

The trial began on February 21 and involved 1,063 people across 68 locations in the US, Europe and Asia.

The first patient to be enrolled was an American who was repatriated after being quarantined on the Diamond Princess cruise ship and was treated at the University of Nebraska Medical Centre.

Neither the patients nor their physicians were aware of which group they belonged to, in order to eliminate unconscious bias.

Peter Horby, an epidemiologist at the University of Oxford who was not involved in the study, said: “We need to see the full results, but if confirmed this would be a fantastic result and great news for the fight against coronavirus.”

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Scott Gottlieb, a former commissioner of the Food and Drug Administration (FDA), wrote on Twitter: “There’s now enough data to support consideration of access under an emergency use authorization.”

THREAD: What is the significance of news today that there may be a drug active against covid? It's a beginning: The start of our ability to build a much better toolbox to combat the infection, mitigate risk today as well as from outbreaks that are likely to occur this Fall. 1/n

— Scott Gottlieb, MD (@ScottGottliebMD) April 29, 2020

This would allow doctors to prescribe the drug outside of the context of clinical trials.

– Blocks viral replication

Remdesivir, which previously failed in trials against Ebola, belongs to a class of drugs that act on the virus directly — as opposed to controlling the abnormal and often lethal autoimmune response it causes.

It mimics one of the four building blocks of RNA and DNA and gets absorbed into the virus’s genome, which in turn stops the pathogen from replicating.

In his remarks to the press, Fauci indicated that since this had yielded some success, it could pave the way for better drugs using the same approach.

There had been mixed news about the intravenous antiviral in recent weeks.

A summary of results posted on the website of the World Health Organization last week showed it failed in a smaller Chinese trial. The Lancet on Wednesday published the formal paper describing that experiment.

In this study of 237 patients in Wuhan, China, doctors found no positive effects of administering the drug compared with a control group of adults, except for those patients who required ventilators.

But the Chinese test had to be halted early because it could not recruit enough people to meet its initial goals, and was considered by many experts to be too small to draw reliable conclusions from.

Fauci said it was “not an adequate study.”

Apart from remdesivir, the antimalarial drugs hydroxychloroquine and chloroquine are also being widely used against coronavirus on a so-called “compassionate basis” pending results from large trials.

Other therapies that are being studied include collecting antibodies from coronavirus survivors and injecting them inpatients, or harvesting antibodies from genetically-engineered mice that were deliberately infected.

[AFP]

 

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